The topics will be taught with special reference to their Pharmaceutical Applications.

Heterocyclic Chemistry

  1. Preparation and properties of medicinally important Heterocyclic Compounds such as pyrol, furan, thiophene, pyridine, pyrimidine and pyrazine.
  2. Preparation and properties of heterocyclic compounds in which benzo-ring is fused with five and six membered ring containing one hetero atom; Indole, Quinoline and Isoquinoline.

Reaction Mechanism

Organic Reaction Mechanism:  Arndt-Eistert reaction, Baeyer-Villiger oxidation, Diels Alder reaction; Grignard’s reaction, Metal Hydride reduction and Wolff Kishner reduction, Friedel Craft’s reaction, Perkin reaction, Cannizzaro’s reaction, Mannich reaction.

Reactive Intermediate And Free Radicals

Introduction: Generation, stability and Reaction of the following Intermediates; Carbocations, Carbanions, Carbenes, Nitrenes, Benzynes.
Type of reactions: An Overview.
Free radicals: Free radical scavengers and their applications.

Carbonium Ion Rearrangements

Pinacol-Pinacolone, Wagner-Meerwein, Wolff, Hofmann and Beckmann rearrangements.


Condensation reaction (Aldol condensation, Favorskii rearrangement, Wittig rearrangement).


Practicals of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities e.g. Organic Preparations: Benzoic acid, Aspirin, Acetanilide, Iodoform, Nitrophenol, 3-nitrophthalic acid, Benzhydrol and 2,4-Dinitro­chlorobenzene.