Note
The topics will be taught with special reference to their Pharmaceutical Applications
General Properties, Chemistry Biological Action, Structure Activity Relationship And Therapeutic Applications Of The Following
- Sulphonamides: Prontosil, sulphanilamide, Sulphapyridine, sulphadimidine, Sulfamethoxazole, Sulfadiazine and Sulfafurazole.
- Antimalarials: 4-Aminoquinolines, 8-Aminoquinolines, 9-Amino acridines, Biguanides, Pyrimidine analogues, Mefloquine and Cinchona alkaloids.
- Diuretics: Mercaptomerin, Meralluride, Thiazides, Sprironolactone, Theophylline, Furosemide, Acetazolamide, Ethacrynic acid and Triameterene.
- Antitubercular Drugs: Ethambutol, Isonicotinic acid, Hydrazid, Rifampacin, Thioguanine, Pyrazinamide, cycloserine, Ethunamide, Cytarabine, 5-Flourouracil and Dacarbazine.
- Antiviral Drugs: Acyclovir, Tromantadine Hydrochloride and Ribavirin
- Immunosuppressant Agents: Azathioprine and Cyclosporin
- Antibiotics: Penicillins, Cephalosporins, Streptomycin, Chloramphenicol, Tetracyclines, Kanamycin and Erythromycin
Note
Practical of the subject shall be designed from time to time on the basis of the above mentioned theoretical topics and availability of the facilities, e.g. Estimation of functional groups; Carboxylic, Hydroxy, Amino and Nitro groups; Determination of Molecular weights of Organic Compounds. Synthesis of Paracetamol, Salicylic Acid, Methyl salicylate, Azobenzene, Benzoic Acid, 5-Hydroxy-1, 3-benzoxazol-2-one, Aspirin, P-nitrosophenol, 3-nitrophthalic acid, o‑Chloro-benzoic acid. Assay of the Drugs like Sulpha drugs, Aspirin, Paracetamol, Benzyl Penicillin. Inorganic Preparations (Note: A minimum of 10 practicals will be conducted).