Course Objectives:
Students will acquire knowledge and understanding about aromatic substitution reactions and oxidation and reduction as well as pericyclic reactions.
Course Contents:
Aromatic Substitution Reactions:
Mechanisms of aromatic reactions including electrophilic and nucleophilic substitutions, effect of substituents on orientation and reactivity.
Oxidation-reductions Reactions:
Common oxidizing and reducing reagents, reactions involving elimination of H, cleavage of C-C bond, replacement of hydrogen by oxygen, and addition of oxygen to substrates, reaction involving replacement of oxygen by hydrogen, removal of oxygen from the substrates and reduction with cleavage.
Pericyclic Reactions:
Introduction to pericyclic reactions, frontier orbital theory, mechanisms of electrocyclic, cycloaddition and sigmatropic reactions.
CHEM-361 Lab:
Experiments involving aromatic substitution, oxidation/reduction reactions and pericyclic reactions, nitration of nitrobenzene to meta-dinitrobenzene, reduction of meta- dinitrobenzene to meta-nitroaniline, sulphonation of aniline, oxidation of benzaldehyde, oxidation of cyclohexanol to cyclohexanone. Preparation of benzoic acid and benzyl alcohol from benzaldehyde using Cannizzaro’s reaction.